2579696-45-8

2579696-45-8 structure

Name: Antimicrobial agent-1
Chemical Name: Antimicrobial agent-1
CAS Number: 2579696-45-8
Molecular Formula: C₂₂H₂₁N₃O₂S
Molecular Weight: 391.49
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-01 18:22:49
Modify Date: 2024-01-10 17:25:47
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines[1].

Name	Antimicrobial agent-1

Description	Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 2 μg/mL (TolC mutant E. coli)[1]
References	[1]. Dokla EME, et al. Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria. Eur J Med Chem. 2020;186:111850.

Molecular Formula	C₂₂H₂₁N₃O₂S
Molecular Weight	391.49