2765785-88-2
2765785-88-2 structure
- Name: ATR-IN-14
- Chemical Name: ATR-IN-14
- CAS Number: 2765785-88-2
- Molecular Formula: C20H20FN7O
- Molecular Weight: 393.42
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
- Create Date: 2022-06-26 21:10:11
- Modify Date: 2024-01-10 09:52:05
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ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
| Name | ATR-IN-14 |
|---|
| Description | ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1]. |
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| Related Catalog | |
| Target |
ATR |
| References |
[1]. Shao-hui Wang, et al. Class of 1,7-naphthyridine compounds and application thereof. WO2022063308A1. |
| Molecular Formula | C20H20FN7O |
|---|---|
| Molecular Weight | 393.42 |