2499499-62-4

2499499-62-4 structure
2499499-62-4 structure
  • Name: BRAF V600E/CRAF-IN-2
  • Chemical Name: BRAF V600E/CRAF-IN-2
  • CAS Number: 2499499-62-4
  • Molecular Formula: C30H30F3N5O2
  • Molecular Weight: 549.59
  • Catalog: Signaling Pathways MAPK/ERK Pathway Raf
  • Create Date: 2022-07-29 11:42:01
  • Modify Date: 2024-01-07 19:45:46
  • BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

Name BRAF V600E/CRAF-IN-2
Description BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].
Related Catalog
References

[1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

Molecular Formula C30H30F3N5O2
Molecular Weight 549.59
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