2499499-62-4

2499499-62-4 structure

Name: BRAF V600E/CRAF-IN-2
Chemical Name: BRAF V600E/CRAF-IN-2
CAS Number: 2499499-62-4
Molecular Formula: C₃₀H₃₀F₃N₅O₂
Molecular Weight: 549.59
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2022-07-29 11:42:01
Modify Date: 2024-01-07 19:45:46
BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

Name	BRAF V600E/CRAF-IN-2

Description	BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
References	[1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

Molecular Formula	C₃₀H₃₀F₃N₅O₂
Molecular Weight	549.59