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331942-46-2

331942-46-2 structure

331942-46-2 structure

Name: DHFR-IN-2
Chemical Name: DHFR-IN-2
CAS Number: 331942-46-2
Molecular Formula: C₁₄H₁₃NO₂
Molecular Weight: 227.26
Catalog: Signaling Pathways Cell Cycle/DNA Damage Antifolate
Create Date: 2022-07-02 18:02:16
Modify Date: 2025-08-26 22:12:36
DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].

Name	DHFR-IN-2

Description	DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR (dihydrofolate reductase from M. tuberculosis), with an IC50 of 7 μM. DHFR-IN-2 can be used for tuberculosis (TB) research[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
Target	IC50: 7 ± 0.13 μM (MtDHFR)[1]
References	[1]. Kronenberger T,et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors. Bioorg Med Chem. 2020 Aug 1;28(15):115600.

Molecular Formula	C₁₄H₁₃NO₂
Molecular Weight	227.26

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