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2169273-66-7

2169273-66-7 structure

2169273-66-7 structure

Name: EphA2 agonist 2
Chemical Name: EphA2 agonist 2
CAS Number: 2169273-66-7
Molecular Formula: C₄₀H₅₆N₁₀O₆
Molecular Weight: 772.94
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Ephrin Receptor
Create Date: 2022-07-02 02:29:50
Modify Date: 2025-08-23 13:37:12
EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB[1].

Name	EphA2 agonist 2

Description	EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor
In Vitro	EphA2 agonist 2 (Lead compound) shows antiproliferation activity with IC50 values of 2.1 ± 1.05 μM and 5.2 ± 2.56 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].
References	[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

Molecular Formula	C₄₀H₅₆N₁₀O₆
Molecular Weight	772.94

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