2428742-58-7

2428742-58-7 structure

2428742-58-7 structure

Name: FGFR3-IN-2
Chemical Name: FGFR3-IN-2
CAS Number: 2428742-58-7
Molecular Formula: C₂₈H₃₉N₉O₄S
Molecular Weight: 597.73
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2022-06-28 09:13:16
Modify Date: 2024-01-09 23:11:51
FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].

Name	FGFR3-IN-2

Description	FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	FGFR3:4.1 nM (IC50) VEGFR2:570 nM (IC50)
References	[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

Molecular Formula	C₂₈H₃₉N₉O₄S
Molecular Weight	597.73