2278278-04-7

2278278-04-7 structure

Name: FLT3/ITD-IN-4
Chemical Name: FLT3/ITD-IN-4
CAS Number: 2278278-04-7
Molecular Formula: C₂₅H₂₂N₄O₅
Molecular Weight: 458.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-07-01 15:44:48
Modify Date: 2024-01-30 21:44:17
FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

Name	FLT3/ITD-IN-4

Description	FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK16/Cyclin Y:1768 nM (EC50) MAP4K4:5737 nM (EC50) FLT3-ITD:2.3 nM (IC50) FLT3 D835Y:4.84 nM (IC50) RET:277 nM (EC50) FLT3:443 nM (EC50) ZAK/MLTK:1069 nM (EC50) DDR2:2494 nM (EC50) EPHA7:3255 nM (EC50) NTRK1:3857 nM (EC50)
References	[1]. Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232.

Molecular Formula	C₂₅H₂₂N₄O₅
Molecular Weight	458.47