2719675-72-4

2719675-72-4 structure

Name: HIV-1 inhibitor-16
Chemical Name: HIV-1 inhibitor-16
CAS Number: 2719675-72-4
Molecular Formula: C₂₃H₁₆F₂N₆
Molecular Weight: 414.41
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-07-02 13:56:47
Modify Date: 2024-01-06 09:15:39
HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1].

Name	HIV-1 inhibitor-16

Description	HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):1.3 nM (EC50) HIV-1 (K103N):5.4 nM (EC50) HIV-1 (E138K):9.2 nM (EC50) HIV-1 (Y181C):22 nM (EC50) HIV-1 (L100I):35 mM (EC50)
References	[1]. Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;65(3):2122-2138.

Molecular Formula	C₂₃H₁₆F₂N₆
Molecular Weight	414.41