2667681-85-6

2667681-85-6 structure

Name: IRAK4-IN-15
Chemical Name: IRAK4-IN-15
CAS Number: 2667681-85-6
Molecular Formula: C₂₅H₂₉FN₁₀
Molecular Weight: 488.56
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-06-30 21:47:19
Modify Date: 2024-01-02 17:20:22
IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

Name	IRAK4-IN-15

Description	IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:0.002 μM (IC50)
In Vitro	IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC50 of 0.21 µM[1]. IRAK4-IN-15 (compound 35) shows selectivity with IC50s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].
References	[1]. Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815.

Molecular Formula	C₂₅H₂₉FN₁₀
Molecular Weight	488.56