2230874-00-5
2230874-00-5 structure
- Name: KRAS inhibitor-12
- Chemical Name: KRAS inhibitor-12
- CAS Number: 2230874-00-5
- Molecular Formula: C19H16Cl2FN5OS
- Molecular Weight: 452.33
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-01 22:17:24
- Modify Date: 2024-01-13 17:50:53
-
KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-12 |
|---|
| Description | KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
KRas G12C:0.537 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C19H16Cl2FN5OS |
|---|---|
| Molecular Weight | 452.33 |