2230873-78-4
2230873-78-4 structure
- Name: KRAS inhibitor-14
- Chemical Name: KRAS inhibitor-14
- CAS Number: 2230873-78-4
- Molecular Formula: C20H15Cl3FN3O2S
- Molecular Weight: 486.77
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-01 12:40:44
- Modify Date: 2024-01-10 17:09:45
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KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-14 |
|---|
| Description | KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.249 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C20H15Cl3FN3O2S |
|---|---|
| Molecular Weight | 486.77 |