1909225-94-0

1909225-94-0 structure

1909225-94-0 structure

Name: MONIRO-1
Chemical Name: MONIRO-1
CAS Number: 1909225-94-0
Molecular Formula: C₂₃H₂₄ClFN₄O₃
Molecular Weight: 458.91
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2022-07-15 09:06:00
Modify Date: 2024-01-14 00:53:47
MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].

Name	MONIRO-1

Description	MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
Target	Cav3.1:3.3 μM (IC50) Cav3.2:1.7 μM (IC50) Cav3.3:7.2 μM (IC50) Cav2.2:34 μM (IC50)
References	[1]. McArthur JR, et al. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. Br J Pharmacol. 2018 Jun;175(12):2284-2295.

Molecular Formula	C₂₃H₂₄ClFN₄O₃
Molecular Weight	458.91