2652001-05-1
2652001-05-1 structure
- Name: P-gp inhibitor 4
- Chemical Name: P-gp inhibitor 4
- CAS Number: 2652001-05-1
- Molecular Formula: C38H38N2O8S2
- Molecular Weight: 714.85
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P-glycoprotein
- Create Date: 2022-07-02 11:41:15
- Modify Date: 2024-01-13 19:35:36
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P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells[1].
| Name | P-gp inhibitor 4 |
|---|
| Description | P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells[1]. |
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| Related Catalog | |
| Target |
EC50: 94 nM (P-glycoprotein)[1] |
| In Vitro | P-gp inhibitor 4 (Compound 8b) (0-1 μM, 48 h) significantly increases the cytotoxic effect of antineoplastic drug with co-administration[1]. P-gp inhibitor 4 does not alter the physiological properties of Caco-2 cells barrier model[1]. P-gp inhibitor 4 selectively reduces the activity of P-gp and increases the transport of multiple P-gp substrates across gastro-intestinal barrier[1]. Cell Proliferation Assay[1] Cell Line: MDCK-MDR1 Concentration: 100 nM, 500 nM and 1 μM Incubation Time: 48 h Result: Showed no cytotoxicity. Significantly increased the cytotoxic effect of antineoplastic drug. Cell Viability Assay[1] Cell Line: Caco-2 cells Concentration: 0.1 nM-100 µM Incubation Time: 72 h Result: Displayed a dose-dependence cytotoxicity that was significant at ≥ 10 μM concentration. Did not reduce cell viability at 100 nM. |
| References |
| Molecular Formula | C38H38N2O8S2 |
|---|---|
| Molecular Weight | 714.85 |