2485732-30-5
2485732-30-5 structure
- Name: PAK1-IN-1
- Chemical Name: PAK1-IN-1
- CAS Number: 2485732-30-5
- Molecular Formula: C26H20ClN5O2
- Molecular Weight: 469.92
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
- Create Date: 2022-07-01 17:58:04
- Modify Date: 2024-01-14 15:25:35
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PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].
| Name | PAK1-IN-1 |
|---|
| Description | PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1]. |
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| Related Catalog | |
| Target |
PAK1:9.8 nM (IC50) PAK4:>10 μM (IC50) |
| In Vitro | PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, HCT-116 cells Concentration: 1 µM Incubation Time: 72 h Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10, 20 µM Incubation Time: 1, 24 h Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner. |
| References |
| Molecular Formula | C26H20ClN5O2 |
|---|---|
| Molecular Weight | 469.92 |