2456295-65-9

2456295-65-9 structure

Name: PI3K/mTOR Inhibitor-7
Chemical Name: PI3K/mTOR Inhibitor-7
CAS Number: 2456295-65-9
Molecular Formula: C₂₉H₃₃N₉O₄
Molecular Weight: 571.63
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2022-07-02 17:18:53
Modify Date: 2024-01-05 17:48:32
PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases[1].

Name	PI3K/mTOR Inhibitor-7

Description	PI3K/mTOR Inhibitor-7 (Compound 19i) is a potent and dual inhibitor of PI3K/mTOR. PI3K/mTOR Inhibitor-7 shows 4.7-fold higher potency than the positive control gedatolisib (0.3 vs. 1.4 μM, IC50 values). PI3K/mTOR Inhibitor-7 significantly suppresses the PI3K/Akt/mTOR signaling pathway at 10 μM. PI3K/mTOR Inhibitor-7 has the potential for the research of cancer diseases[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Wang L, et al. Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors. Eur J Med Chem. 2020 Oct 15;204:112637

Molecular Formula	C₂₉H₃₃N₉O₄
Molecular Weight	571.63