2408639-81-4

2408639-81-4 structure
2408639-81-4 structure
  • Name: Topoisomerase I inhibitor 7
  • Chemical Name: Topoisomerase I inhibitor 7
  • CAS Number: 2408639-81-4
  • Molecular Formula: C22H19N3O5
  • Molecular Weight: 405.40
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
  • Create Date: 2022-06-27 10:37:28
  • Modify Date: 2025-08-25 21:37:34
  • Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor drug candidates among the heteroarene-fused anthraquinones[1].

Name Topoisomerase I inhibitor 7
Description Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor drug candidates among the heteroarene-fused anthraquinones[1].
Related Catalog
References

[1]. Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294.

Molecular Formula C22H19N3O5
Molecular Weight 405.40
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