838819-70-8

838819-70-8 structure

838819-70-8 structure

Name: YM-244769
Chemical Name: YM-244769
CAS Number: 838819-70-8
Molecular Formula: C₂₆H₂₂FN₃O₃
Molecular Weight: 443.47
Catalog: Research Areas Neurological Disease
Create Date: 2022-07-11 15:48:41
Modify Date: 2024-01-14 10:17:07
YM-244769 is a potent NCX (Na+/Ca2+ exchange) inhibitor that preferentially inhibits NCX3, with an IC50 of 18 nM. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage[1].

Name	YM-244769

Description	YM-244769 is a potent NCX (Na+/Ca2+ exchange) inhibitor that preferentially inhibits NCX3, with an IC50 of 18 nM. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 18 nM (NCX3)[1]
In Vitro	YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+ uptake via NCX3; the inhibition is 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2[1].
References	[1]. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.

Molecular Formula	C₂₆H₂₂FN₃O₃
Molecular Weight	443.47