2434630-29-0

2434630-29-0 structure

Name: γ-Secretase modulator 11
Chemical Name: γ-Secretase modulator 11
CAS Number: 2434630-29-0
Molecular Formula: C₂₈H₂₂F₂N₄O₂
Molecular Weight: 484.50
Catalog: Research Areas Neurological Disease
Create Date: 2022-07-01 08:02:18
Modify Date: 2025-08-26 16:54:48
5-{8-[(3,4'- difluoro [1,1'- biphenyl]-4-yl) methoxy] - 2-methylimidazo [1,2-a] pyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.

Name	γ-Secretase modulator 11

Description	5-{8-[(3,4'- difluoro [1,1'- biphenyl]-4-yl) methoxy] - 2-methylimidazo [1,2-a] pyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Sekioka R,et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):115455.

Molecular Formula	C₂₈H₂₂F₂N₄O₂
Molecular Weight	484.50