2765218-56-0
2765218-56-0 structure
- Name: 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
- Chemical Name: 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
- CAS Number: 2765218-56-0
- Molecular Formula: C16H15N3O2S
- Molecular Weight: 313.37
- Create Date: 2022-09-18 21:57:36
- Modify Date: 2024-01-22 19:46:46
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PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation.
| Name | 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- |
|---|
| Description | PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermis through proliferation. |
|---|---|
| In Vitro | PY-60 robustly increased the levels of YAP-controlled transcripts (that is, ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (that is, MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1). PY-60 induced luciferase activity in 293A-TEAD-LUC cells in the presence or absence of serum when cells were plated at high cell density with EC50s of 1.5 and 1.6 µM, respectively. PY-60 also promoted the association of YAP and TEAD proteins in cells in a dose-dependent manner and induced the nuclear localization of YAP in response to increased cell density[1]. |
| In Vivo | PY-60 (10 uM) promoted a dramatic expansion of keratinocytes and K14-positive precursors. PY-60 resulted in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1]. |
| References | 1. Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17(7):767-775. |
| Molecular Formula | C16H15N3O2S |
|---|---|
| Molecular Weight | 313.37 |