2742707-47-5
2742707-47-5 structure
- Name: AChE/BuChE-IN-3
- Chemical Name: AChE/BuChE-IN-3
- CAS Number: 2742707-47-5
- Molecular Formula: C30H30F3N3O6
- Molecular Weight: 585.57
- Catalog: Signaling Pathways Neuronal Signaling AChE
- Create Date: 2022-08-28 10:10:49
- Modify Date: 2024-04-10 17:48:38
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AChE/BuChE-IN-3 (compound C4) is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1].
| Name | AChE/BuChE-IN-3 |
|---|
| Description | AChE/BuChE-IN-3 (compound C4) is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1]. |
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| Related Catalog | |
| Target |
IC50: 5.77 μM (BuChE), 0.65 μM (AChE)[1] |
| In Vitro | AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities[1]. Cell Viability Assay Cell Line: SH-SY5Y[1] Concentration: 12.5 μM, 25 μM, 50 μM and 100 μM Incubation Time: 48 hours Result: Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities. |
| References |
| Molecular Formula | C30H30F3N3O6 |
|---|---|
| Molecular Weight | 585.57 |