2390042-05-2
2390042-05-2 structure
- Name: AChE-IN-14
- Chemical Name: AChE-IN-14
- CAS Number: 2390042-05-2
- Molecular Formula: C28H35NO3
- Molecular Weight: 433.58
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2022-08-06 15:08:10
- Modify Date: 2025-08-20 13:12:15
-
AChE-IN-14 is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1].
| Name | AChE-IN-14 |
|---|
| Description | AChE-IN-14 is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1]. |
|---|---|
| Related Catalog | |
| In Vitro | AChE-IN-14 (compound 5) has a good affinity to human H3 receptor with a Ki value of 159.8 nM in HEK293 cells[1]. AChE-IN-14 (compound 5) has a high orally activity and cannot cross the blood-brain barrier[1]. AChE-IN-14 (compound 5) (10 μM, 5 min) inhibits hAChE with an IC50 value of 0.48 μM and represents the non-competitive type of eeAChE (Ki = 176 nM) and eqBuChE (Ki = 281 nM) inhibition[1]. |
| References |
| Molecular Formula | C28H35NO3 |
|---|---|
| Molecular Weight | 433.58 |