2490154-44-2
2490154-44-2 structure
- Name: Anti-MRSA agent 5
- Chemical Name: Anti-MRSA agent 5
- CAS Number: 2490154-44-2
- Molecular Formula: C25H22N4O4
- Molecular Weight: 442.47
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-08-10 19:14:42
- Modify Date: 2024-01-16 11:36:31
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Anti-MRSA agent is a potent MRSA agent with MIC50 values of 0.38 μg/mL and has low hERG activity with an IC50 values of >40 μM. Anti-MRSA agent also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance[1].
| Name | Anti-MRSA agent 5 |
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| Description | Anti-MRSA agent is a potent MRSA agent with MIC50 values of 0.38 μg/mL and has low hERG activity with an IC50 values of >40 μM. Anti-MRSA agent also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance[1]. |
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| Related Catalog | |
| Target |
MIC: 0.38 μg/mL (MRSA); IC50: >40 Μm (hERG) |
| In Vitro | Anti-MRSA agent (B14) is highly selective toxic in bacterial cells. Anti-MRSA agent has marginal inhibitory activities with an IC50 values of exceeding 40 μM. Anti-MRSA agent has strong antibacterial activity for all five clinical isolates of MRSA (NRS-1, NRS-70, NRS-100, NRS-108, NRS-271) with MIC values between < 0.17 and 0.69 μg/mL. Anti-MRSA agent inhibits all three clinical isolates of fluoroquinolone-resistant MRSA (19-25, 19-26, 19-27) and exhibits good potency against VISA[1]. Cell Cytotoxicity Assay Cell Line: A549, MDA-MB-231, PC-3, ABAE. Concentration: 0–400 μM Incubation Time: 48h Result: Showed Anti-MRSA agent has marginal inhibitory activities with anIC50 exceeding 40 μM. B14 also displayed highly selective toxicity toward bacterial cells. |
| References |
| Molecular Formula | C25H22N4O4 |
|---|---|
| Molecular Weight | 442.47 |