2416400-32-1

2416400-32-1 structure

Name: DNA Gyrase-IN-4
Chemical Name: DNA Gyrase-IN-4
CAS Number: 2416400-32-1
Molecular Formula: C₂₂H₁₅Cl₂NO₄S
Molecular Weight: 460.33
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-15 12:00:31
Modify Date: 2024-01-10 10:02:37
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively[1].

Name	DNA Gyrase-IN-4

Description	DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.13 μM (DNA gyrase)[1]
References	[1]. Liu H, et al. Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity. Bioorg Chem. 2020 Jul;100:103907.

Molecular Formula	C₂₂H₁₅Cl₂NO₄S
Molecular Weight	460.33