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879730-44-6

879730-44-6 structure

879730-44-6 structure

Name: EGFR/HER2/CDK9-IN-1
Chemical Name: EGFR/HER2/CDK9-IN-1
CAS Number: 879730-44-6
Molecular Formula: C₂₃H₂₁N₃O₃S₂
Molecular Weight: 451.56
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-09-17 19:40:17
Modify Date: 2024-01-09 16:08:15
EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity[1].

Name	EGFR/HER2/CDK9-IN-1

Description	EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.

Molecular Formula	C₂₃H₂₁N₃O₃S₂
Molecular Weight	451.56

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