63302-01-2

63302-01-2 structure
63302-01-2 structure
  • Name: L-DOPA sodium
  • Chemical Name: L-DOPA sodium
  • CAS Number: 63302-01-2
  • Molecular Formula: C9H10NNaO4
  • Molecular Weight: 219.17
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2022-08-05 17:29:23
  • Modify Date: 2024-01-12 15:10:49
  • L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research[1][2][3].

Name L-DOPA sodium
Description L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vivo L-DOPA sodium (20 mg/kg; orally) reduces Rotenone-induced motor dysfunction[3]. L-DOPA sodium (0-100 mg/kg; orally) reverses tactile, cold and heat allodynia in neuropathic rat without any side effect in sprague-Dawley rats[4]. Animal Model: C57BL/6J mice (7-week-old)[3] Dosage: 20 mg/kg Administration: Orally Result: Reduced Rotenone-induced motor dysfunction. Animal Model: Sprague-Dawley rats[4] Dosage: 10, 30, 50, 70, and 100 mg/kg Administration: Orally Result: Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.
References

[1]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10.

[2]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(4):273-80. Epub 2007 Nov 7.

[3]. Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 3;10:237.

[4]. Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 1;54(2):330-5.

Molecular Formula C9H10NNaO4
Molecular Weight 219.17