2105918-34-9

2105918-34-9 structure

Name: MAO-B-IN-13
Chemical Name: MAO-B-IN-13
CAS Number: 2105918-34-9
Molecular Formula: C₁₈H₁₉NO₃
Molecular Weight: 297.35
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2022-08-16 01:50:24
Modify Date: 2024-01-08 09:33:12
MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor with an IC50 value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease[1].

Name	MAO-B-IN-13

Description	MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor with an IC50 value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-B:10 nM (IC50)
In Vitro	MAO-B-IN-13 (compound 12a) (1 μM, 10 μM and 50 μM; 48 hours) has neuroprotective effect on H2O2-induced PC-12 cell injury[1].
References	[1]. Li W, et al. Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease. Bioorg Chem. 2020 Apr;97:103707.

Molecular Formula	C₁₈H₁₉NO₃
Molecular Weight	297.35