2304527-20-4

2304527-20-4 structure
2304527-20-4 structure
  • Name: Topoisomerase II inhibitor 12
  • Chemical Name: Topoisomerase II inhibitor 12
  • CAS Number: 2304527-20-4
  • Molecular Formula: C40H63N3O4
  • Molecular Weight: 649.95
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
  • Create Date: 2022-08-26 17:48:13
  • Modify Date: 2024-04-03 07:02:56
  • Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].

Name Topoisomerase II inhibitor 12
Description Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].
Related Catalog
In Vitro Topoisomerase II inhibitor 12 (Compound 8c) shows anti-proliferative activities with IC50 values of 8.80 ± 0.12, 7.13 ± 0.20, 6.56 ± 0.15, 10.99 ± 0.23, 10.71 ± 0.03 and 13.27 ± 0.32 μM against HepG2, HCT116, MDA-MB-231, Hela, K562 and PDLSC cells, respectively[1].
References

[1]. Xie XW, et al. Design, synthesis, bioevaluation of LFC- and PA-tethered anthraquinone analogues of mitoxantrone. Bioorg Chem. 2020 Aug;101:104005.

Molecular Formula C40H63N3O4
Molecular Weight 649.95
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