2259860-24-5
2259860-24-5 structure
- Name: Zimberelimab
- Chemical Name: Zimberelimab
- CAS Number: 2259860-24-5
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
- Create Date: 2022-08-03 19:59:56
- Modify Date: 2024-01-10 21:24:34
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Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with high affinity and selectivity. Zimberelimab shows antitumor activities and can be used for various cancers research including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma[1].
| Name | Zimberelimab |
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| Description | Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with high affinity and selectivity. Zimberelimab shows antitumor activities and can be used for various cancers research including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma[1]. |
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| Related Catalog | |
| In Vitro | Zimberelimab has an EC50 of 210 pM for human PD-1 but does not bind to related CD28 family receptors, such as ICOS, CD28 and CTLA-4[1]. Zimberelimab binding to cell-expressed human PD-1 inhibits the interaction of the receptor with both human PD-L1 and PD-L2 with IC50s of 580 pM and 670 pM, respectively[1]. Zimberelimab dose-dependently enhances IFN-g production and proliferation by CD4+ T cells, saturating at concentrations below 100 pM[1]. |
| References |
[1]. Markham A. Zimberelimab: First Approval. Drugs. 2021 Nov;81(17):2063-2068. |
| No Any Chemical & Physical Properties |