2434630-30-3

2434630-30-3 structure

Name: γ-Secretase modulator 11 hydrochloride
Chemical Name: γ-Secretase modulator 11 hydrochloride
CAS Number: 2434630-30-3
Molecular Formula: C₂₈H₂₃ClF₂N₄O₂
Molecular Weight: 520.96
Catalog: Research Areas Neurological Disease
Create Date: 2022-08-23 17:40:40
Modify Date: 2024-04-08 17:02:20
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].

Name	γ-Secretase modulator 11 hydrochloride

Description	γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 0.029 µM nM (γ-Secretase)[1]
References	[1]. Sekioka R, et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):115455.

Molecular Formula	C₂₈H₂₃ClF₂N₄O₂
Molecular Weight	520.96