2433837-65-9

2433837-65-9 structure

Name: EGFR-IN-69
Chemical Name: EGFR-IN-69
CAS Number: 2433837-65-9
Molecular Formula: C₃₁H₃₇Cl₂N₇O₃S
Molecular Weight: 658.64
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-09-12 18:53:14
Modify Date: 2024-01-07 07:40:03
EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research[1].

Name	EGFR-IN-69

Description	EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR L858R/T790M/C797S:4.3 ± 0.9 nM (IC50) EGFRL858R/T790M:6.6 ± 0.8 nM (IC50) EGFRdel19 T790M C797S:25.6 ± 7.5 nM (IC50) EGFRWT:816.0 ± 82 nM (IC50)
References	[1]. Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858.

Molecular Formula	C₃₁H₃₇Cl₂N₇O₃S
Molecular Weight	658.64