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2676155-98-7

2676155-98-7 structure

2676155-98-7 structure

Name: EGFR-IN-71
Chemical Name: EGFR-IN-71
CAS Number: 2676155-98-7
Molecular Formula: C₁₆H₉ClIN₃
Molecular Weight: 405.62
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-08-31 16:46:40
Modify Date: 2024-01-24 11:53:27
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1].

Name	EGFR-IN-71

Description	EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 3.7 μM (EGFR)[1]
In Vitro	EGFR-IN-71 (compound 41) (0-100 μM; 72 h) has inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines[1]. Cell Viability Assay[1] Cell Line: U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 Concentration: 0-100 μM Incubation Time: 72 h Result: Exhibited inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines with IC50s of 9.1 μM, 16 μM, 0.48 μM, 25 μM, 0.96 μM and 8.0 μM, respectively.
References	[1]. Bieberich AA, et al. Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27;12(1):12820.

Molecular Formula	C₁₆H₉ClIN₃
Molecular Weight	405.62

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