1353570-53-2
1353570-53-2 structure
- Name: gamma-secretase modulator 5
- Chemical Name: gamma-secretase modulator 5
- CAS Number: 1353570-53-2
- Molecular Formula: C22H25N7OS
- Molecular Weight: 435.55
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-09-17 12:48:08
- Modify Date: 2024-01-12 09:44:39
-
gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer's disease[1].
| Name | gamma-secretase modulator 5 |
|---|
| Description | gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer's disease[1]. |
|---|---|
| Related Catalog | |
| Target |
Aβ38:305 nM (EC50) Aβ40:104 nM (IC50) Aβ42:60 nM (IC50) |
| In Vitro | gamma-secretase modulator 5 (compound 22d) (1-10 μM, 24 h) does not affect the function of the APP751 enzyme and not inhibit Notching processing in H4 human neuroglioma cells over-expressing human APP751[1]. gamma-secretase modulator 5 (compound 22d) acts on Aβ38 with the EC50 value of 305 nM and acts on Aβ40 with the IC50 value of 104 nM[1]. |
| In Vivo | The pharmacokinetic parameters of gamma-secretase modulator 5 (compound 22d) in male CD-1 mice[1]. Parameters IV PO Dose (mg/kg) 1 5 Cmax (ng/mL) 824 705 Tmax (h) 0.083 0.25 t1/2 (h) 0.5 - AUClast (ng•h/mL) 443 1089 AUCinf (ng•h/mL) 463 1243 Cl (mL/h/kg) 2159 - Vss (mL/kg) 1413 - F (%) 100 53.7 |
| References |
| Molecular Formula | C22H25N7OS |
|---|---|
| Molecular Weight | 435.55 |