1812188-83-2

1812188-83-2 structure

Name: IRAK4-IN-16
Chemical Name: IRAK4-IN-16
CAS Number: 1812188-83-2
Molecular Formula: C₁₇H₂₀F₂N₈O
Molecular Weight: 390.39
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2022-09-01 16:56:17
Modify Date: 2024-09-18 19:14:14
IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].

Name	IRAK4-IN-16

Description	IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:2.5 ± 0.8 nM (IC50)
References	[1]. Chen Y, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092.

Molecular Formula	C₁₇H₂₀F₂N₈O
Molecular Weight	390.39