694488-83-0
694488-83-0 structure
- Name: MFI8
- Chemical Name: MFI8
- CAS Number: 694488-83-0
- Molecular Formula: C16H18ClNO
- Molecular Weight: 275.77
- Catalog: Research Areas Others
- Create Date: 2022-09-16 11:45:04
- Modify Date: 2025-09-18 19:38:13
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MFI8 is a small molecule inhibitor of mitochondrial fusion[1].
| Name | MFI8 |
|---|
| Description | MFI8 is a small molecule inhibitor of mitochondrial fusion[1]. |
|---|---|
| Related Catalog | |
| Target |
Mitofusin[1] |
| In Vitro | MFI8 (20 μM, 6 h) reduces significantly mitochondrial aspect ratio with an EC50 of 4.8 μM, and inhibits mitochondrial fusion via mitofusins and subsequently promoting mitochondrial fission[1]. MFI8 possesses functional groups that meet the criteria of the pharmacophore model to interact with mitofusins and promotes mitochondrial fission[1]. MFI8 binds to the HR2 domain of MFN2, modulates MFN conformation and complexes, and alters mitochondrial functionality[1]. MFI8 (0-20 μM, 6 h) concentration-responsively increases caspase-3/7 activity, induces cytochrome c release and decreases membrane potential in a mitofusin-dependent manner. MFI8 also induces DNA damage and induces cell death in combination with BV6 SMAC (second mitochondria-derived activator of caspases) mimetic[1]. |
| References |
| Molecular Formula | C16H18ClNO |
|---|---|
| Molecular Weight | 275.77 |