346607-37-2
346607-37-2 structure
- Name: Sitafloxacin hydrochloride
- Chemical Name: Sitafloxacin hydrochloride
- CAS Number: 346607-37-2
- Molecular Formula: C19H19Cl2F2N3O3
- Molecular Weight: 446.28
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-09-07 09:59:49
- Modify Date: 2024-04-09 08:02:20
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Sitafloxacin (DU6859a) hydrochloride is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin hydrochloride shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin hydrochloride can be used for the research of respiratory tract infection and urinary tract infection[1][2].
| Name | Sitafloxacin hydrochloride |
|---|
| Description | Sitafloxacin (DU6859a) hydrochloride is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin hydrochloride shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin hydrochloride can be used for the research of respiratory tract infection and urinary tract infection[1][2]. |
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| Related Catalog | |
| In Vitro | Sitafloxacin (DU6859a) hydrochloride shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parC mutant 1026523 streptococcus pneumoniae stran, respectively[1]. Sitafloxacin (DU6859a) hydrochloride shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively[1]. Sitafloxacin (DU6859a) hydrochloride shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively[1]. |
| In Vivo | Sitafloxacin (DU6859a; 12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) hydrochloride has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling[2]. Animal Model: BALB/c female mice[2] Dosage: 12.5, 25, 50 and 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells |
| References |
| Molecular Formula | C19H19Cl2F2N3O3 |
|---|---|
| Molecular Weight | 446.28 |