736945-96-3
736945-96-3 structure
- Name: TRPC3/6-IN-1
- Chemical Name: TRPC3/6-IN-1
- CAS Number: 736945-96-3
- Molecular Formula: C20H19N3O2S
- Molecular Weight: 365.45
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2022-09-12 23:09:35
- Modify Date: 2024-04-06 19:46:59
-
TRPC3/6-IN-1 is a potent selectivity and orally active molecule blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].
| Name | TRPC3/6-IN-1 |
|---|
| Description | TRPC3/6-IN-1 is a potent selectivity and orally active molecule blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1]. |
|---|---|
| Related Catalog | |
| Target |
hTRPC3:1260 nM (IC50) hTRPC6:500 nM (IC50) |
| In Vitro | TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively[1]. |
| In Vivo | TRPC3/6-IN-1 has good blocking activity for TRPC3 and TRPC6 in rats[1]. Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1]. Compd Dose(iv)(mg/kg) Cmax(iv)(ng/ml) CL(iv)(ml/min/kg) MRT(iv)(h) DNAUC(iv)(h•kg/L) %F 3 0.93 250 120 0.3 0.14 ~1 |
| References |
| Molecular Formula | C20H19N3O2S |
|---|---|
| Molecular Weight | 365.45 |