2785430-85-3
2785430-85-3 structure
- Name: ALK5-IN-29
- Chemical Name: ALK5-IN-29
- CAS Number: 2785430-85-3
- Molecular Formula: C24H25FN8
- Molecular Weight: 444.51
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
- Create Date: 2022-10-12 21:52:33
- Modify Date: 2024-01-16 13:12:12
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ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC50 value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1].
| Name | ALK5-IN-29 |
|---|
| Description | ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC50 value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1]. |
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| Related Catalog | |
| Target |
IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor)[1] |
| In Vitro | ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC50 value of ≤10 nM[1]. ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC50 value of ≤10 nM[1]. ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC50 value of ≤100 nM[1]. |
| References |
[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent. WO2022126133A1. |
| Molecular Formula | C24H25FN8 |
|---|---|
| Molecular Weight | 444.51 |