2085844-54-6

2085844-54-6 structure

Name: CC-90002
Chemical Name: CC-90002
CAS Number: 2085844-54-6
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2022-10-12 09:50:02
Modify Date: 2024-04-09 09:43:27
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors[1][2].

Name	CC-90002

Description	CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
In Vitro	CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value[1]. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range[1]. CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines[1].
In Vivo	CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models[1].
References	[1]. Rama Krishna Narla, et al. The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo. [2]. Zhongxing Jiang, et al. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021 Oct 30;14(1):180.

No Any Chemical & Physical Properties