1374959-91-7

1374959-91-7 structure
1374959-91-7 structure
  • Name: FAK-IN-8
  • Chemical Name: FAK-IN-8
  • CAS Number: 1374959-91-7
  • Molecular Formula: C15H9Cl2N3O2S
  • Molecular Weight: 366.22
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
  • Create Date: 2022-10-09 18:51:14
  • Modify Date: 2024-09-16 17:12:58
  • FAK-IN-8 (compound 5h) is a FAK inhibitor (IC50=5.32 µM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research[1].

Name FAK-IN-8
Description FAK-IN-8 (compound 5h) is a FAK inhibitor (IC50=5.32 µM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research[1].
Related Catalog
Target

FAK:5.32 μM (IC50)

In Vitro FAK-IN-8 (0-10 µM; 48 h) inhibits MCF-7 and B16-F10 cells proliferation[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 and B16-F10 cells Concentration: 0-10 µM Incubation Time: 48 h Result: Exhibited anti-proliferative activity against MCF-7 and B16-F10 cells with IC50 values of 3.57 and 3.52 µM, respectively.
References

[1]. Yang XH, et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95.

Molecular Formula C15H9Cl2N3O2S
Molecular Weight 366.22
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