2032436-79-4

2032436-79-4 structure

2032436-79-4 structure

Name: MAO-B-IN-15
Chemical Name: MAO-B-IN-15
CAS Number: 2032436-79-4
Molecular Formula: C₁₇H₁₈FNO₂
Molecular Weight: 287.33
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2022-10-12 06:51:03
Modify Date: 2024-04-09 19:19:09
MAO-B-IN-15 is a selective MAO-B inhibitor (IC50: 13.5 μM) that forms π-π interaction with Tyr 326 residue. MAO-B-IN-15 can be used in the research of Parkinson’s disease[1].

Name	MAO-B-IN-15

Description	MAO-B-IN-15 is a selective MAO-B inhibitor (IC50: 13.5 μM) that forms π-π interaction with Tyr 326 residue. MAO-B-IN-15 can be used in the research of Parkinson’s disease[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	hMAO-B:13.5 μM (IC50) hMAO-A:>100 μM (IC50)
In Vitro	MAO-B-IN-15 (Compound 4i, 0.01-1000 μM, 1 h) dose-dependently inhibits MAO-B activity[1]. MAO-B-IN-15 (10 μM, 24 h) has no effect on cell viability of SH-SY5Y cells[1].
References	[1]. Makito Yamada, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. https://doi.org/10.1021/acsmedchemlett.2c00228.

Molecular Formula	C₁₇H₁₈FNO₂
Molecular Weight	287.33