1346113-84-5

1346113-84-5 structure

Name: PKM2 activator 3
Chemical Name: PKM2 activator 3
CAS Number: 1346113-84-5
Molecular Formula: C₁₅H₁₁ClF₂N₂O₃S
Molecular Weight: 372.77
Catalog: Research Areas Cancer
Create Date: 2022-11-05 18:06:45
Modify Date: 2024-04-03 17:01:58
PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer[1]. (AC50: the concentration which gives 50% activation of enzyme.)

Name	PKM2 activator 3

Description	PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer[1]. (AC50: the concentration which gives 50% activation of enzyme.)
Related Catalog	Research Areas >> Cancer
Target	PKM2[1]
In Vivo	PKM2 activator 3 (compound 66) has good Caco-2 permeability, a low efflux ratio (0.84) and high microsomal stability (t1/2 = 277.2 min in human liver microsomes and 117.5 min in mouse liver microsomes)[1].
References	[1]. Walsh MJ, et al. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6322-7.

Molecular Formula	C₁₅H₁₁ClF₂N₂O₃S
Molecular Weight	372.77