2650074-56-7

2650074-56-7 structure

Name: Seconeolitsine
Chemical Name: Seconeolitsine
CAS Number: 2650074-56-7
Molecular Formula: C₁₉H₁₇NO₄
Molecular Weight: 323.34
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-16 18:29:55
Modify Date: 2024-01-08 10:42:09
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics[1].

Name	Seconeolitsine

Description	Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Topoisomerase I:17 μM (IC50)
In Vitro	Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC50 value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid[1]. Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC50 values of 8 μM for CipR42, CipR68 and CipR15[1]. Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1[1]. Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner[1]. Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability[1].
In Vivo	Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo[1].
References	[1]. María Teresa García, et al. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumonia. J Biol Chem. 2011 Feb 25;286(8):6402-13.

Molecular Formula	C₁₉H₁₇NO₄
Molecular Weight	323.34

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