210346-40-0

210346-40-0 structure
210346-40-0 structure
  • Name: Topoisomerase I inhibitor 8
  • Chemical Name: Topoisomerase I inhibitor 8
  • CAS Number: 210346-40-0
  • Molecular Formula: C24H21FN2O4
  • Molecular Weight: 420.43
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
  • Create Date: 2022-11-22 13:40:17
  • Modify Date: 2025-08-26 22:24:05
  • Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].

Name Topoisomerase I inhibitor 8
Description Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].
Related Catalog
Target

Topoisomerase I

In Vitro Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1]. Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1].
References

[1]. Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18.

Molecular Formula C24H21FN2O4
Molecular Weight 420.43
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