210346-40-0

210346-40-0 structure

Name: Topoisomerase I inhibitor 8
Chemical Name: Topoisomerase I inhibitor 8
CAS Number: 210346-40-0
Molecular Formula: C₂₄H₂₁FN₂O₄
Molecular Weight: 420.43
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-11-22 13:40:17
Modify Date: 2024-01-12 19:52:23
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].

Name	Topoisomerase I inhibitor 8

Description	Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
In Vitro	Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1]. Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1].
References	[1]. Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18.

Molecular Formula	C₂₄H₂₁FN₂O₄
Molecular Weight	420.43