2738485-98-6
2738485-98-6 structure
- Name: TREM2 agonist-2
- Chemical Name: TREM2 agonist-2
- CAS Number: 2738485-98-6
- Molecular Formula: C24H23ClFN5O
- Molecular Weight: 451.92
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-10-31 22:17:46
- Modify Date: 2024-01-05 10:01:06
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TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1].
| Name | TREM2 agonist-2 |
|---|
| Description | TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TREM2 agonist-2 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: 16 hours Result: Showed an EC50 value <0.05 μM. |
| In Vivo | TREM2 agonist-2 (oral gavage; 50 mg/kg; twice daily; one day) finds TREM2 target engagement on microglia[1]. Animal Model: Transgenic mice knock-in hTREM2-CV[1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg; twice daily; one day Result: Increased genes associated with the adaptive immune response, innate immune response, microglia function, cytokine signalling, and cell cycle in hippocampus from animals. |
| References |
| Molecular Formula | C24H23ClFN5O |
|---|---|
| Molecular Weight | 451.92 |