186610-88-8

186610-88-8 structure

Name: hVEGF-IN-2
Chemical Name: way-607500
CAS Number: 186610-88-8
Molecular Formula: C₁₉H₁₈N₂O₂
Molecular Weight: 306.37
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2022-11-21 14:52:58
Modify Date: 2024-01-10 18:52:53
hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific drugs[1].

Name	way-607500

Description	hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific drugs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR1:2.5 μM (IC50) PDGF:33.1 μM (IC50)
In Vitro	hVEGF-IN-2 (0-100 μM) shows the inhibitory activities to particular RTKs at the cellular level with IC50 values of 2.5, 33.1, ＞100, ＞100 and ＞100 nM for VEGF, PDGF, EGF, HER-2 and IGF-1, respectively[1].

Molecular Formula	C₁₉H₁₈N₂O₂
Molecular Weight	306.37