214745-43-4
214745-43-4 structure
- Name: Efalizumab
- Chemical Name: Efalizumab
- CAS Number: 214745-43-4
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2022-11-05 20:55:26
- Modify Date: 2024-01-14 18:52:52
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Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research[1].
| Name | Efalizumab |
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| Description | Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research[1]. |
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| Related Catalog | |
| In Vitro | Efalizumab (78 ng/mL-5 mg/mL) induces a leukocytosis and downregulates LFA-1 expression on T cells in the peripheral blood[3]. Efalizumab (78 ng/mL-5 mg/mL) downregulates plate-bound, anti-CD3-stimulated proliferation of PBMC[3]. |
| In Vivo | Efalizumab shows side effects include bacterial sepsis, viral meningitis, invasive fungal disease and progressive multifocal leukoencephalopathy (PML), a brain infection caused by reactivation of latent JC virus infection[2]. |
| No Any Chemical & Physical Properties |