2260887-09-8

2260887-09-8 structure

Name	TH-Z93

Description	TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	FPPS[1]
In Vivo	TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1]. Animal Model: B16-OVA cells (s.c.) xenograft mice model[1]. Dosage: 20 μg Administration: Intraperitoneal injection (i.p.) Result: Intraperitoneal injection (i.p.)
References	[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.

Molecular Formula	C₁₂H₂₂N₂O₇P₂
Molecular Weight	368.26