451515-89-2

451515-89-2 structure

Name: Topoisomerase II inhibitor 13
Chemical Name: WAY-323966
CAS Number: 451515-89-2
Molecular Formula: C₂₂H₂₃N₉
Molecular Weight: 413.48
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-12-14 06:11:08
Modify Date: 2024-04-06 09:51:28
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].

Name	WAY-323966
Synonyms	6-Amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile 5H-Pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile, 6-amino-7-(1H-benzimidazol-2-yl)-5-[3-(diethylamino)propyl]- TCMDC-123680

Description	Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II
In Vitro	Topoisomerase II inhibitor 13 (compound 3m) (20 μM，50 μM) 在 20 μM 时发挥强烈的抑制作用，几乎完全抑制 Topo II 活性[1]。 Topoisomerase II inhibitor 13 抑制癌细胞增殖，IC50 分别为 25.85 μM (MDA-MB-231)、1.82 μM (A549)、10.38 μM (K562)、1.73 μM (Raji)、1.23 μM (HL-60) 和 0.87 μM (HL-60/MX2)[1]。
References	[1]. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.