507289-11-4
507289-11-4 structure
- Name: Cenderitide
- Chemical Name: Cenderitide
- CAS Number: 507289-11-4
- Molecular Formula: C158H263N49O50S3
- Molecular Weight: 3745.27
- Catalog: Signaling Pathways GPCR/G Protein Guanylate Cyclase
- Create Date: 2022-11-21 17:26:55
- Modify Date: 2024-01-22 17:17:22
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Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research[1][2][3].
| Name | Cenderitide |
|---|
| Description | Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research[1][2][3]. |
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| Related Catalog | |
| In Vitro | Cenderitide has antiproliferative, anti-fibrotic, and anti-hypertrophic properties[1]. |
| In Vivo | In vivo in normal canines, Cenderitide (10, 50, and 100 ng/kg) is a potent cGMP stimulator that has renal enhancing and cardiac unloading effects, with less reduction of blood pressure[1][4]. |
| Molecular Formula | C158H263N49O50S3 |
|---|---|
| Molecular Weight | 3745.27 |