2368927-41-5
2368927-41-5 structure
- Name: Ph-HTBA
- Chemical Name: Ph-HTBA
- CAS Number: 2368927-41-5
- Molecular Formula: C19H18O3
- Molecular Weight: 294.34
- Catalog: Signaling Pathways Neuronal Signaling CaMK
- Create Date: 2022-11-21 10:19:59
- Modify Date: 2024-01-09 18:11:50
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Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].
| Name | Ph-HTBA |
|---|
| Description | Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1]. |
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| Related Catalog | |
| Target |
Kd: 757 nM (CaMKIIα)[1] |
| In Vitro | Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM[1]. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM[1]. Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding[1]. |
| In Vivo | Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice[1]. |
| Molecular Formula | C19H18O3 |
|---|---|
| Molecular Weight | 294.34 |